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Article

A role for the BDNF gene Val66Met polymorphism in schizophrenia? A comprehensive review.

Neuroscience and biobehavioral reviews - 1 Apr 2015

Notaras Michael, Hill Rachel, van den Buuse Maarten

Abstract excerpt

Schizophrenia is believed to arise from complex gene-environment interactions. Brain-derived neurotrophic factor (BDNF) is involved in neuronal development, differentiation and plasticity. A functional single nucleotide polymorphism that results in a valine (Val) to methionine (Met) substitution at codon 66 (Val66Met) results in the aberrant sorting and release of mature BDNF through the activity-dependent...

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Source

Identifiers

PMID: 25562189
DOI: 10.1016/j.neubiorev.2014.12.016

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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