Brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism differentially predicts hippocampal function in medication-free patients with schizophrenia.

doi:10.1038/mp.2012.187

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Brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism differentially predicts hippocampal function in medication-free patients with schizophrenia.

Molecular psychiatry - 1 Jun 2013

Eisenberg D P, Ianni A M, Wei S-M, Kohn P D, Kolachana B, Apud J, Weinberger D R, Berman K F

Abstract excerpt

A Val(66)Met single-nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene impairs activity-dependent BDNF release in cultured hippocampal neurons and predicts impaired memory and exaggerated basal hippocampal activity in healthy humans. Several clinical genetic association studies along with multi-modal evidence for hippocampal dysfunction in schizophrenia indirectly suggest a...

Topics

Adult
Brain-Derived Neurotrophic Factor
Decision Support Techniques
Deuterium Oxide
Female
Genotype
Hippocampus
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Memory, Short-Term

Methionine

Neuropsychological Tests

Oxygen

Polymorphism, Single Nucleotide

Positron-Emission Tomography

Rest

Source

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Identifiers

PMID: 23319002
DOI: 10.1038/mp.2012.187
PMCID: PMC3628926

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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