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Article

Regression of Atherosclerosis Is Characterized by Broad Changes in the Plaque Macrophage Transcriptome

27 Jun 2012

Abstract excerpt

We have developed a mouse model of atherosclerotic plaque regression in which an atherosclerotic aortic arch from a hyperlipidemic donor is transplanted into a normolipidemic recipient, resulting in rapid elimination of cholesterol and monocyte-derived macrophage cells (CD68+) from transplanted vessel walls. To gain a comprehensive view of the differences in gene expression patterns in macrophages associated with...

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PMID: 22761902
DOI: 10.1371/journal.pone.0039790

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