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Article

Anti-inflammatory immune skewing is atheroprotective: Apoe−/−FcγRIIb−/− mice develop fibrous carotid plaques.

Journal of the American Heart Association - 1 Dec 2014

Harmon Erin Y, Fronhofer Van, Keller Rebecca S, Feustel Paul J, Zhu Xinmei, Xu Hao, Avram Dorina, Jones David M, Nagarajan Shanmugam, Lennartz Michelle R

Abstract excerpt

BACKGROUND: Stroke, caused by carotid plaque rupture, is a major cause of death in the United States. Whereas vulnerable human plaques have higher Fc receptor (FcγR) expression than their stable counterparts, how FcγR expression impacts plaque histology is unknown. We investigated the role of FcγRIIb in carotid plaque development and stability in apolipoprotein (Apo)e−/− and Apoe−/−FcγRIIb−/− double knockout...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25516435
DOI: 10.1161/JAHA.114.001232
PMCID: PMC4338708

Genes

TNF

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