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Article

Toll-Like Receptor 9 Inactivation Alleviated Atherosclerotic Progression and Inhibited Macrophage Polarized to M1 Phenotype in ApoE-/- Mice.

Disease markers - 1 Jan 2015

Ma Chunmei, Ouyang Qiufang, Huang Ziyang, Chen Xiaoqing, Lin Ye, Hu Weiping, Lin Ling

Abstract excerpt

OBJECTIVE: Toll-like receptor 9 (TLR9) is involved in many inflammatory diseases, but its role in atherosclerosis remains controversial. This study aimed to investigate the role of TLR9 in atherosclerosis development and macrophage polarization. METHODS: ApoE(-/-) mice were treated with vehicle or IRS869 for 12 weeks. Plaque vulnerability was assessed with immunohistochemical analysis, picro-sirius red, and oil...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26257462
DOI: 10.1155/2015/909572
PMCID: PMC4518170

Genes

TLR9

Provenance

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