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Article

The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go.

Scientific reports - 17 Feb 2016

Xu Ying, Orlandi Cesare, Cao Yan, Yang Shengyan, Choi Chan-Il, Pagadala Vijayakanth, Birnbaumer Lutz, Martemyanov Kirill A, Vardi Noga

Abstract excerpt

Transmission from photoreceptors to ON bipolar cells in mammalian retina is mediated by a sign-inverting cascade. Upon binding glutamate, the metabotropic glutamate receptor mGluR6 activates the heterotrimeric G-protein Gαoβ3γ13, and this leads to closure of the TRPM1 channel (melastatin). TRPM1 is thought to be constitutively open, but the mechanism that leads to its closure is unclear. We investigated this...

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Identifiers

PMID: 26883481
DOI: 10.1038/srep20940
PMCID: PMC4756708

Genes

TRPM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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