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Article

Kir2.4 surface expression and basal current are affected by heterotrimeric G-proteins.

The Journal of biological chemistry - 8 Mar 2013

Sulaiman Pyroja, Xu Ying, Fina Marie E, Tummala Shanti R, Ramakrishnan Hariharasubramanian, Dhingra Anuradha, Vardi Noga

Abstract excerpt

Kir2.4, a strongly rectifying potassium channel that is localized to neurons and is especially abundant in retina, was fished with yeast two-hybrid screen using a constitutively active Gαo1. Here, we wished to determine whether and how Gαo affects this channel. Using transfected HEK 293 cells and retinal tissue, we showed that Kir2.4 interacts with Gαo, and this interaction is stronger with the GDP-bound form of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23339194
DOI: 10.1074/jbc.M112.412791
PMCID: PMC3591649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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