Article

Ectopic expression of two cone opsins in mouse RGCs results in opposite responses to light stimulation, likely due to differential G protein activation

2025-09-15

Abstract excerpt

Retinitis pigmentosa, a leading cause of inherited blindness, results in photoreceptor degeneration that current optogenetic approaches aim to address through microbial opsin expression in retinal ganglion cells (RGCs). While these microbial proteins restore light sensitivity, their clinical potential remains limited by low light sensitivity and immunogenicity risks. Recent efforts have focused on vertebrate opsin...

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Literature Corpus work: e35e4f96-7c12-5d3f-94d7-00ce406ae0ca
DOI: 10.1101/2025.09.10.675309

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