Article
A Single Residue Mutation in the Gαq Subunit of the G Protein Complex Causes Blindness in Drosophila.
G3 (Bethesda, Md.) - 4 Jan 2018
Cao Jinguo, Bollepalli Murali K, Hu Yuhui, Zhang Jin, Li Qiang, Li Hongmei, Chang Hua, Xiao Feng, Hardie Roger C, Rong Yikang S, Hu Wen
Abstract excerpt
Heterotrimeric G proteins play central roles in many signaling pathways, including the phototransduction cascade in animals. However, the degree of involvement of the G protein subunit Gαq is not clear since animals with previously reported strong loss-of-function mutations remain responsive to light stimuli. We recovered a new allele of Gαq in Drosophila that abolishes light response in a conventional...
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