Article
Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.
Leukemia - 1 Nov 2016
Parker H, Rose-Zerilli M J J, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J, Ljungström V, Wojdacz T K, Chaplin T, Roghanian A, Davis Z, Parker A, Tausch E, Ntoufa S, Ramos S, Robbe P, Alsolami R, Steele A J, Packham G, Rodríguez-Vicente A E, Brown L, McNicholl F, Forconi F, Pettitt A, Hillmen P, Dyer M, Cragg M S, Chelala C, Oakes C C, Rosenquist R, Stamatopoulos K, Stilgenbauer S, Knight S, Schuh A, Oscier D G, Strefford J C
Abstract excerpt
Histone methyltransferases (HMTs) are important epigenetic regulators of gene transcription and are disrupted at the genomic level in a spectrum of human tumours including haematological malignancies. Using high-resolution single nucleotide polymorphism (SNP) arrays, we identified recurrent deletions of the SETD2 locus in 3% (8/261) of chronic lymphocytic leukaemia (CLL) patients. Further validation in two...
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