Article
Mutational neighbourhood and mutation supply rate constrain adaptation in Pseudomonas aeruginosa.
Proceedings. Biological sciences - 22 Feb 2010
Hall Alex R, Griffiths Victoria F, MacLean R Craig, Colegrave Nick
Abstract excerpt
Understanding adaptation by natural selection requires understanding the genetic factors that determine which beneficial mutations are available for selection. Here, using experimental evolution of rifampicin-resistant Pseudomonas aeruginosa, we show that different genotypes vary in their capacity for adaptation to the cost of antibiotic resistance. We then use sequence data to show that the beneficial mutations...
Topics
- Adaptation, Biological
- Bacterial Proteins
- Base Sequence
- DNA Primers
- Directed Molecular Evolution
- Drug Resistance, Microbial
- Genotype
- Molecular Sequence Data
- Mutation
- Pseudomonas aeruginosa
- Rifampin