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Article

Polygenic phenotypic plasticity moderates the effects of severe childhood abuse on depressive symptom severity in adulthood: A 5-year prospective cohort study.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Feb 2017

Bousman Chad A, Gunn Jane M, Potiriadis Maria, Everall Ian P

Abstract excerpt

Objective To test the phenotypic plasticity framework using a polygenic approach in a prospective depression cohort of primary care attendees with and without histories of severe childhood abuse. Methods Depressive symptoms were assessed at baseline and annually for 5 years post-baseline using the Primary Care Evaluation of Mental Disorders Patient Health Questionnaire-9 (PHQ-9) among 288 adult primary care...

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PMID: 26878222
DOI: 10.3109/15622975.2016.1153710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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