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Article

Genetic susceptibility for major depressive disorder associates with trajectories of depressive symptoms across childhood and adolescence.

Journal of child psychology and psychiatry, and allied disciplines - 1 Jul 2021

Lussier Alexandre A, Hawrilenko Matthew, Wang Min-Jung, Choi Karmel W, Cerutti Janine, Zhu Yiwen, Dunn Erin C

Abstract excerpt

BACKGROUND: Early-onset depression during childhood and adolescence is associated with a worse course of illness and outcome than adult onset. However, the genetic factors that influence risk for early-onset depression remain mostly unknown. Using data collected over 13 years, we examined whether polygenic risk scores (PRS) that capture genetic risk for depression were associated with depressive symptom...

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Identifiers

PMID: 33125721
DOI: 10.1111/jcpp.13342
PMCID: PMC9886425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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