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Article

Polygenic risk moderation of stressful life events in alcohol use disorder severity.

BMC psychiatry - 23 Feb 2026

Agabani Zena, Al Chalabi Nzaar, De Luca Vincenzo, Le Foll Bernard, Hassan Ahmed N

Abstract excerpt

BACKGROUND: Advances in gene–environment (GE) research underscore the need for novel statistical methods to clarify how social stress and genetic liability jointly influence Alcohol Use Disorder (AUD). This study examined the effect of Stressful Life Events (SLEs) on past-year DSM-5 AUD severity using propensity score matching and tested whether Polygenic Risk Scores (PRS) moderated the association between stress...

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Share to Alcoholism
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Severity of Illness Index

Share to Stress, Psychological

Source

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Identifiers

PMID: 41731382
DOI: 10.1186/s12888-026-07920-6
PMCID: PMC13037033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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