HPA-axis multilocus genetic variation moderates longitudinal link between friendship quality and adolescent depressive symptoms after childhood abuse.

Abstract excerpt

BACKGROUND: Studies indicate that genetic variations associated with the functioning of the hypothalamic-pituitary-adrenal (HPA) axis can influence the relationship between environmental stressors and depressive symptoms, but examining gene-environment interactions with single polymorphisms limits power. OBJECTIVE: This study examined a multilocus genetic profile score (MGPS) for HPA-axis function and...

Topics

• Humans
• Female
• Male
• Adolescent
• Hypothalamo-Hypophyseal System
• Pituitary-Adrenal System
• Depression