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Article

Polygenic risk for depression, anxiety and neuroticism are associated with the severity and rate of change in depressive symptoms across adolescence.

Journal of child psychology and psychiatry, and allied disciplines - 1 Dec 2021

Kwong Alex S F, Morris Tim T, Pearson Rebecca M, Timpson Nicholas J, Rice Frances, Stergiakouli Evie, Tilling Kate

Abstract excerpt

BACKGROUND: Adolescence marks a period where depression will commonly onset. Twin studies show that genetic influences play a role in how depression develops and changes across adolescence. Recent genome-wide association studies highlight that common genetic variants - which can be combined into polygenic risk scores (PRS) - are also implicated in depression. However, the role of PRS in adolescent depression and...

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PMID: 33778956
DOI: 10.1111/jcpp.13422

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