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Article

The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition.

Nature communications - 15 Feb 2016

Weyemi Urbain, Redon Christophe E, Choudhuri Rohini, Aziz Towqir, Maeda Daisuke, Boufraqech Myriem, Parekh Palak R, Sethi Taresh K, Kasoji Manjula, Abrams Natalie, Merchant Anand, Rajapakse Vinodh N, Bonner William M

Abstract excerpt

The epithelial-mesenchymal transition (EMT), considered essential for metastatic cancer, has been a focus of much research, but important questions remain. Here, we show that silencing or removing H2A.X, a histone H2A variant involved in cellular DNA repair and robust growth, induces mesenchymal-like characteristics including activation of EMT transcription factors, Slug and ZEB1, in HCT116 human colon cancer...

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Source

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Identifiers

PMID: 26876487
DOI: 10.1038/ncomms10711
PMCID: PMC4756313

Genes

ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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