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Article

Loss of p53 epigenetically modulates epithelial to mesenchymal transition in colorectal cancer

26 Feb 2024

Abstract excerpt

Epithelial to Mesenchymal transition (EMT) drives cancer metastasis and is governed by genetic and epigenetic alterations at multiple levels of regulation. It is well established that loss/mutation of p53 confers oncogenic function to cancer cells and promotes metastasis. Though transcription factors like ZEB1, SLUG, SNAIL and TWIST have been implied in EMT signalling, p53 mediated alterations in the epigenetic...

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PMID: 38412660
DOI: 10.1016/j.tranon.2023.101848

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