Article
ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1.
Gut - 1 Apr 2017
de Barrios Oriol, Győrffy Balázs, Fernández-Aceñero María Jesús, Sánchez-Tilló Ester, Sánchez-Moral Lidia, Siles Laura, Esteve-Arenys Anna, Roué Gaël, Casal José I, Darling Douglas S, Castells Antoni, Postigo Antonio
Abstract excerpt
OBJECTIVE: Understand the role of ZEB1 in the tumour initiation and progression beyond inducing an epithelial-to-mesenchymal transition. DESIGN: Expression of the transcription factor ZEB1 associates with a worse prognosis in most cancers, including colorectal carcinomas (CRCs). The study uses survival analysis, in vivo mouse transgenic and xenograft models, gene expression arrays, immunostaining and gene and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.