Article
Loss of colonic fidelity enables multilineage plasticity and metastasis.
Nature - 1 Aug 2025
Cammareri Patrizia, Raponi Michela, Hong Yourae, Billard Caroline V, Peckett Nat, Zhu Yujia, Velez-Bravo Fausto D, Younger Nicholas T, Dunican Donnchadh S, Pohl Sebastian Ö-G, Bastem Akan Aslihan, Doleschall Nora J, Falconer John, White Mark, Quinn Jean, Pennel Kathryn, Garau Roberta, Malla Sudhir B, Dunne Philip D, Meehan Richard R, Sansom Owen J, Edwards Joanne, Dunlop Malcolm G, Din Farhat V N, Tejpar Sabine, Steele Colin W, Myant Kevin B
Abstract excerpt
Cancer cell plasticity enables the acquisition of new phenotypic features and is implicated as a major driver of metastatic progression1,2. Metastasis occurs mostly in the absence of additional genetic alterations3-5, which suggests that epigenetic mechanisms are important6. However, they remain poorly defined. Here we identify the chromatin-remodelling enzyme ATRX as a key regulator of colonic lineage fidelity...
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