Article

Up-regulated transcriptional regulators in mutant RAS gene signatures: a time-resolved multi-omics study in generic epithelial cell models

2024-06-06

Abstract excerpt

<h4>ABSTRACT</h4> The expression of mutated RAS genes drives extensive transcriptome alterations. Perturbation experiments have shown that the transcriptional responses to downstream effector pathways are partially unique and non-overlapping, suggesting a modular organization of the RAS-driven expression program. However, the relationship between individual deregulated transcription factors and the entire cancer...

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Literature Corpus work: 6f0d35d6-efa4-5f24-90ee-aba813be7c75
DOI: 10.1101/2024.06.04.597297

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