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Article

Cardiac Sirt1 mediates the cardioprotective effect of caloric restriction by suppressing local complement system activation after ischemia-reperfusion.

American journal of physiology. Heart and circulatory physiology - 15 Apr 2016

Yamamoto Tsunehisa, Tamaki Kayoko, Shirakawa Kohsuke, Ito Kentaro, Yan Xiaoxiang, Katsumata Yoshinori, Anzai Atsushi, Matsuhashi Tomohiro, Endo Jin, Inaba Takaaki, Tsubota Kazuo, Sano Motoaki, Fukuda Keiichi, Shinmura Ken

Abstract excerpt

Caloric restriction (CR) confers cardioprotection against ischemia-reperfusion (I/R) injury. We previously found the essential roles of endothelial nitric oxide synthase in the development of CR-induced cardioprotection and Sirt1 activation during CR (Shinmura K, Tamaki K, Ito K, Yan X, Yamamoto T, Katsumata Y, Matsuhashi T, Sano M, Fukuda K, Suematsu M, Ishii I. Indispensable role of endothelial nitric oxide...

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Identifiers

PMID: 26873964
DOI: 10.1152/ajpheart.00676.2015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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