Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD38 Deficiency Protects the Heart from Ischemia/Reperfusion Injury through Activating SIRT1/FOXOs-Mediated Antioxidative Stress Pathway.

Oxidative medicine and cellular longevity - 1 Jan 2016

Guan Xiao-Hui, Liu Xiao-Hong, Hong Xuan, Zhao Ning, Xiao Yun-Fei, Wang Ling-Fang, Tang Ling, Jiang Kai, Qian Yi-Song, Deng Ke-Yu, Ji Guangju, Fu Mingui, Xin Hong-Bo

Abstract excerpt

Ischemia/reperfusion (I/R) injury induces irreversible oxidative stress damage to the cardiac muscle. We previously observed that CD38 deficiency remarkably protects mouse embryonic fibroblasts (MEFs) from oxidative stress-induced injury. However, whether CD38 deficiency protects from I/R injury in the heart is not explored. Here, we showed that the hearts of CD38 deficient mice or wild type mice supplied with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-ribosyl Cyclase
Share to ADP-ribosyl Cyclase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein O3

Share to Myocardial Infarction

Share to Myocardial Reperfusion Injury

Share to Myocardium

Share to NADPH Oxidases

Share to Sirtuin 1

Source

Open in PubMed Open full text

Identifiers

PMID: 27547294
DOI: 10.1155/2016/7410257
PMCID: PMC4983367

Genes

FOXO1
SIRT1
FOXO3
NOX4
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD38 Deficiency Protects the Heart from Ischemia/Reperfusion Injury through Activating SIRT1/FOXOs-Mediated Antioxidative Stress Pathway.PMID 27547294Read ↗

Cardiomyocyte specific CD38 deletion protects heart from acute myocardial infarction by activating Sirt3 signaling pathwaySemantic proximity Read ↗

Downregulation of Sirt6 by CD38 promotes cell senescence and agingSemantic proximity Read ↗

Myocardial IGF2R is a critical mediator of inflammation and fibrosis after ischemia-reperfusion injurySemantic proximity Read ↗

The Serum of MEF2D Expression in Patients with Myocardial Infarction, May be Clinical Indicators and it Mediated ROS Signaling by HDAC5Semantic proximity Read ↗

Hypertrophic preconditioning attenuates post-myocardial infarction injury through deacetylation of isocitrate dehydrogenase 2.Semantic proximity Read ↗

miRNA-541-5p regulates myocardial ischemia–reperfusion injury by targeting ferroptosisSemantic proximity Read ↗

Upregulation of CD44 attenuates hypoxia/reoxygenation-induced ferroptosis and injury in cardiomyocytes by CD44/SLC7A11 pathwaySemantic proximity Read ↗

LncRNA-AK138945 Regulates Myocardial Ischemia-Reperfusion Injury Via the miR-1-GRP94 Signaling PathwaySemantic proximity Read ↗

Exploring key regulators involved in cardiac ischemic preconditioning through proteomic analysis in ischemia reperfusion mice modelsSemantic proximity Read ↗

High-Throughput Sequencing to Investigate the Expression and Potential Role of Differentially Expressed microRNAs in Myocardial Cells after Ischemia-Reperfusion InjurySemantic proximity Read ↗

TLR2 activates AP-1 to facilitate CTGF transcription and stimulate doxorubicin-induced myocardial injurySemantic proximity Read ↗

<i>Nrf2</i>and Cardiovascular DefenseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.