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Article

Cardiomyocyte-specific deletion of Sirt1 gene sensitizes myocardium to ischaemia and reperfusion injury.

Cardiovascular research - 1 May 2018

Wang Lin, Quan Nanhu, Sun Wanqing, Chen Xu, Cates Courtney, Rousselle Thomas, Zhou Xinchun, Zhao Xuezhong, Li Ji

Abstract excerpt

Aims: A longevity gene, Sirtuin 1 (SIRT1) and energy sensor AMP-activated protein kinase (AMPK) have common activators such as caloric restriction, oxidative stress, and exercise. The objective of this study is to characterize the role of cardiomyocyte SIRT1 in age-related impaired ischemic AMPK activation and increased susceptibility to ischemic insults. Methods and results: Mice were subjected to ligation of...

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Share to Acetyl-CoA Carboxylase
Share to AMP-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria, Heart

Share to Myocardial Contraction

Share to Myocardial Reperfusion Injury

Share to Myocytes, Cardiac

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Share to Ventricular Function, Left

Source

Open in PubMed Open full text

Identifiers

PMID: 29409011
DOI: 10.1093/cvr/cvy033
PMCID: PMC5909650

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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