Article

Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Autophagy and Mitophagy

2025-09-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Sirtuin 1 (SIRT1), a NAD + -dependent protein deacetylase, regulates cardiovascular inflammation by modulating cellular stress, inhibiting NLRP3 activation, and promoting the clearance of damaged mitochondria. However, its precise role in the pathogenesis of Kawasaki disease (KD), a pediatric systemic vasculitis and the leading cause of acquired heart disease in children, r...

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Literature Corpus work: 5a071544-ff8f-5c52-9e25-60195c836e45
DOI: 10.1101/2025.09.04.671113

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