Article
Saffron (Crocus sativus) intake provides nutritional preconditioning against myocardial ischemia-reperfusion injury in Wild Type and ApoE(-/-) mice: Involvement of Nrf2 activation.
Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Oct 2017
Efentakis P, Rizakou A, Christodoulou E, Chatzianastasiou A, López M G, León R, Balafas E, Kadoglou N P E, Tseti I, Skaltsa H, Kostomitsopoulos N, Iliodromitis E K, Valsami G, Andreadou I
Abstract excerpt
BACKGROUND AND AIMS: Saffron is an antioxidant herbal derivative; however, its efficacy as a nutritional cardioprotective agent has not been fully elucidated. We investigated the cardioprotective properties of a standardized saffron aqueous extract (SFE) against ischemia/reperfusion (I/R) injury in Wild-Type (WT) and ApoE(-/-) mice and the underlying molecular mechanisms. METHODS AND RESULTS: WT and ApoE(-/-)...
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