Article
Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival.
Molecular and cellular biology - 1 Mar 2011
Beier Ulf H, Wang Liqing, Bhatti Tricia R, Liu Yujie, Han Rongxiang, Ge Guanghui, Hancock Wayne W
Abstract excerpt
Sirtuin 1 (Sirt1), a class III histone/protein deacetylase, is central to cellular metabolism, stress responses, and aging, but its contributions to various host immune functions have been little investigated. To study the role of Sirt1 in T cell functions, we undertook targeted deletions by mating mice with a floxed Sirt1 gene to mice expressing CD4-cre or Foxp3-cre recombinase, respectively. We found that Sirt1...
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