Article
The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Science immunology - 16 Apr 2021
Lim Jia Jia, Jones Claerwen M, Loh Tiing Jen, Ting Yi Tian, Zareie Pirooz, Loh Khai L, Felix Nathan J, Suri Anish, McKinnon Murray, Stevenaert Frederik, Sharma Ravi K, Klareskog Lars, Malmström Vivianne, Baker Daniel G, Purcell Anthony W, Reid Hugh H, La Gruta Nicole L, Rossjohn Jamie
Abstract excerpt
Individuals expressing HLA-DR4 bearing the shared susceptibility epitope (SE) have an increased risk of developing rheumatoid arthritis (RA). Posttranslational modification of self-proteins via citrullination leads to the formation of neoantigens that can be presented by HLA-DR4 SE allomorphs. However, in T cell-mediated autoimmunity, the interplay between the HLA molecule, posttranslationally modified...
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