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Article

Impact of Heparan Sulfate Binding on Transduction of Retina by Recombinant Adeno-Associated Virus Vectors.

Journal of virology - 1 Apr 2016

Boye Sanford L, Bennett Antonette, Scalabrino Miranda L, McCullough K Tyler, Van Vliet Kim, Choudhury Shreyasi, Ruan Qing, Peterson James, Agbandje-McKenna Mavis, Boye Shannon E

Abstract excerpt

UNLABELLED: Adeno-associated viruses (AAVs) currently are being developed to efficiently transduce the retina following noninvasive, intravitreal (Ivt) injection. However, a major barrier encountered by intravitreally delivered AAVs is the inner limiting membrane (ILM), a basement membrane rich in heparan sulfate (HS) proteoglycan. The goal of this study was to determine the impact of HS binding on retinal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Injections, Intravenous

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Source

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Identifiers

PMID: 26865709
DOI: 10.1128/JVI.00200-16
PMCID: PMC4810560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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