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Article

Retinal transduction profiling of diverse AAV serotypes via intravitreal injection

12 Aug 2025

Abstract excerpt

ABSTRACT Optimizing adeno-associated virus (AAV) capsid and dosing selection is critical for the clinical translation of retinal gene therapy. This study aims to provide a comprehensive reference by comparing the transduction efficiency, cellular tropisms, and temporal retinal expression patterns of various AAV serotypes for intravitreal retinal gene therapy. A series of AAV vectors were intravitreally injected...

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PMID: 40793790
DOI: 10.1128/jvi.00637-25

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