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Article

High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2009

Petrs-Silva Hilda, Dinculescu Astra, Li Qiuhong, Min Seok-Hong, Chiodo Vince, Pang Ji-Jing, Zhong Li, Zolotukhin Sergei, Srivastava Arun, Lewin Alfred S, Hauswirth William W

Abstract excerpt

Vectors derived from adeno-associated viruses (AAVs) have become important gene delivery tools for the treatment of many inherited ocular diseases in well-characterized animal models. Previous studies have determined that the viral capsid plays an essential role in the cellular tropism and efficiency of transgene expression. Recently, it was shown that phosphorylation of surface-exposed tyrosine residues from...

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Identifiers

PMID: 19066593
DOI: 10.1038/mt.2008.269
PMCID: PMC2835095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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