Article
Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat.
PloS one - 1 Jan 2015
Bogner Barbara, Boye Sanford L, Min Seok Hong, Peterson James J, Ruan Qing, Zhang Zhonghong, Reitsamer Herbert A, Hauswirth William W, Boye Shannon E
Abstract excerpt
BACKGROUND: Adeno associated virus (AAV) is well known for its ability to deliver transgenes to retina and to mediate improvements in animal models and patients with inherited retinal disease. Although the field is less advanced, there is growing interest in AAV's ability to target cells of the anterior segment. The purpose of our study was to fully articulate a reliable and reproducible method for injecting the...
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