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Article

Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection

31 Mar 2017

Abstract excerpt

Widespread gene transfer to the retina is challenging as it requires vector systems to overcome physical and biochemical barriers to enter and diffuse throughout retinal tissue. We investigated whether exosome-associated adeno-associated virus, (exo-AAV) enabled broad retinal targeting following intravitreal (IVT) injection, as exosomes have been shown to traverse biological barriers and mediate widespread...

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PMID: 28361998
DOI: 10.1038/srep45329

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