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Article

Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding.

Journal of virology - 1 Jun 2003

Opie Shaun R, Warrington Kenneth H, Agbandje-McKenna Mavis, Zolotukhin Sergei, Muzyczka Nicholas

Abstract excerpt

The adeno-associated virus type 2 (AAV2) uses heparan sulfate proteoglycan (HSPG) as its primary cellular receptor. In order to identify amino acids within the capsid of AAV2 that contribute to HSPG association, we used biochemical information about heparin and heparin sulfate, AAV serotype protein sequence alignments, and data from previous capsid studies to select residues for mutagenesis. Charged-to-alanine...

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Identifiers

PMID: 12768018
DOI: 10.1128/jvi.77.12.6995-7006.2003
PMCID: PMC156206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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