Article

Mannose-coupled AAV2: a second generation AAV vector for increased retinal gene therapy efficiency

2022-12-01

Abstract excerpt

Inherited retinal diseases are a leading and untreatable cause of blindness and are therefore candidate diseases for gene therapy. Recombinant vectors derived from adeno-associated virus (rAAV) are currently the most promising vehicles for in vivo therapeutic gene delivery to the retina. However, there is a need for novel AAV-based vectors with greater efficacy for ophthalmic applications, as underscored by recen...

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Literature Corpus work: 566c733e-7b2b-566f-b9de-81b6dee5bbab
DOI: 10.1101/2022.12.01.518481

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