Article

Immunobiology of a rationally-designed AAV2 capsid following intravitreal delivery in mice

2022-09-30

Abstract excerpt

Adeno-associated virus serotype 2 (AAV2) is a viral vector that can be used to deliver therapeutic genes to diseased cells in the retina. One strategy for altering AAV2 vectors involves the mutation of phosphodegron residues, which are thought to be phosphorylated/ubiquitinated in the cytosol, facilitating degradation of the vector and the inhibition of transduction. As such, mutation of phosphodegron residues hav...

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Identifiers and source

Literature Corpus work: 92482ad2-dd5d-5b20-b9c3-611981a2ea66
DOI: 10.21203/rs.3.rs-1991309/v1

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