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Article

Suprachoroidal Delivery of Viral and Nonviral Gene Therapy for Retinal Diseases

7 Apr 2020

Abstract excerpt

Retinal gene therapy is a rapidly growing field with numerous clinical trials underway, and route of delivery is a critical contributor to its success. Subretinal administration, which involves pars plana vitrectomy in the operating room, offers targeted delivery to retinal-pigment epithelium cells and photoreceptors. Due to the immune-privileged nature of the subretinal space, the risk of an immune reaction...

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PMID: 32255727
DOI: 10.1089/jop.2019.0126

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