Article

Novel Intravitreal Retina-Targeting and Immune-Evading Adeno-Associated Virus Capsid Variant

2024-09-27

Abstract excerpt

Retinal diseases are an important focus of in vivo gene therapy, for which adeno-associated virus is a preferred vector. Intravitreal injection is a highly desirable delivery route because it is much simpler, safer and inexpensive than the main alternative subretinal injection. However, existing capsids have low efficiency, require high doses and are susceptible to neutralization by antibodies that are present in...

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Literature Corpus work: 6e2eb0c6-ee33-5df7-902d-5ee6c5ae03a2
DOI: 10.20944/preprints202409.2179.v1

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