Efficient genome-wide association testing of gene-environment interaction in case-parent trios.

doi:10.1093/aje/kwq097

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Article

Efficient genome-wide association testing of gene-environment interaction in case-parent trios.

American journal of epidemiology - 1 Jul 2010

Gauderman W James, Thomas Duncan C, Murcray Cassandra E, Conti David, Li Dalin, Lewinger Juan Pablo

Abstract excerpt

Complex trait variation is likely to be explained by the combined effects of genes, environmental factors, and gene x environment (G x E) interaction. The authors introduce a novel 2-step method for detecting a G x E interaction in a genome-wide association study (GWAS) of case-parent trios. The method utilizes 2 sources of G x E information in a trio sample to construct a screening step and a testing step....

Topics

Environment
Epidemiologic Methods
Gene Frequency
Genetic Predisposition to Disease
Genetic Testing
Genome, Human
Genome-Wide Association Study
Humans
Models, Genetic
Parents
Polymorphism, Single Nucleotide

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Identifiers

PMID: 20543031
DOI: 10.1093/aje/kwq097
PMCID: PMC2915477

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