Article

Complete Reference Genome and Pangenome Expand Biologically Relevant Information for Genome-Wide DNA Methylation Analysis Using Short-Read Sequencing and Array Data

2024-10-11

Abstract excerpt

<h4>Background</h4> The new complete telomere-to-telomere human genome assembly, T2T-CHM13, and the first draft of the human pangenome reference provide unique opportunities to update the reference genome for epigenetics investigations and clinical research. However, it is largely unclear how these reference genome updates may impact DNA methylation (DNAm) analysis. <h4>Results</h4> Compared to the previous GRCh...

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Literature Corpus work: 7e468030-883c-5481-8fd9-7b2436b5ccd9
DOI: 10.1101/2024.10.07.617116

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