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Article

Acute lymphoblastic leukemia in the context of RASopathies.

European journal of medical genetics - 1 Mar 2016

Cavé Hélène, Caye Aurélie, Strullu Marion, Aladjidi Nathalie, Vignal Cédric, Ferster Alice, Méchinaud Françoise, Domenech Carine, Pierri Filomena, Contet Audrey, Cacheux Valère, Irving Julie, Kratz Christian, Clavel Jacqueline, Verloes Alain

Abstract excerpt

Noonan syndrome is associated with a range of malignancies including acute lymphoblastic leukemia (ALL). However, little information is available regarding the frequency, natural history, characteristics and prognosis of ALL in Noonan syndrome or RASopathies in general. Cross-referencing data from a large prospective cohort of 1176 patients having a molecularly confirmed RASopathy with data from the French...

Topics

Adolescent
Child
Child, Preschool
Female
Genotype
Humans
Infant
Infant, Newborn
Male
Mutation
Neoplasms, Second Primary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Noonan Syndrome

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Prevalence

Protein Tyrosine Phosphatase, Non-Receptor Type 11

SOS1 Protein

ras Proteins

Source

Identifiers

PMID: 26855057
DOI: 10.1016/j.ejmg.2016.01.003

Genes

PTPN11
BRAF
HRAS
SOS1

Provenance

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