Article
Cytogenetic abnormalities and TP53 and RAS gene profiles of childhood acute lymphoblastic leukemia in Morocco.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie - 1 May 2024
Skhoun Hanaa, El Fessikh Meriem, El Alaoui Al Abdallaoui Mohamed, Khattab Mohammed, Belkhayat Aziza, Chebihi Zahra Takki, Hassani Amale, Abilkassem Rachid, Agadr Aomar, Dakka Nadia, El Baghdadi Jamila
Abstract excerpt
BACKGROUND: Recurrent genetic abnormalities affecting pivotal signaling pathways are the hallmark of childhood acute lymphoblastic leukemia (ALL). The identification of these aberrations remains clinically important. Therefore, we sought to determine the cytogenetic profile and the mutational status of TP53 and RAS genes among Moroccan childhood cases of ALL. METHODS: In total, 35 patients with childhood ALL were...
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