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Clinical and genetic characteristics of children with acute lymphoblastic leukemia and Li–Fraumeni syndrome

12 Feb 2021

Abstract excerpt

Approximately 10% of cases of childhood cancer arise in the context of a cancer predisposition syndrome (CPS) [ 1 ]. Among the rare CPS, Li–Fraumeni syndrome (LFS, MIM#151623) is relatively common and estimated to account for >1% of cases of childhood cancer [ 2 ]. LFS is a dominantly inherited condition caused by pathogenic germline variants in the TP53 tumor suppressor gene [ 3 , 4 ]. Children with LFS are...

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PMID: 33580201
DOI: 10.1038/s41375-021-01163-y

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