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Article

RAS diseases in children.

Haematologica - 1 Nov 2014

Niemeyer Charlotte M

Abstract excerpt

RAS genes encode a family of 21 kDa proteins that are an essential hub for a number of survival, proliferation, differentiation and senescence pathways. Signaling of the RAS-GTPases through the RAF-MEK-ERK pathway, the first identified mitogen-associated protein kinase (MAPK) cascade is essential in development. A group of genetic syndromes, named "RASopathies", had been identified which are caused by...

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Source

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Identifiers

PMID: 25420281
DOI: 10.3324/haematol.2014.114595
PMCID: PMC4222471

Genes

CBL
KRAS
NRAS
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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