Article
RAS diseases in children.
Haematologica - 1 Nov 2014
Niemeyer Charlotte M
Abstract excerpt
RAS genes encode a family of 21 kDa proteins that are an essential hub for a number of survival, proliferation, differentiation and senescence pathways. Signaling of the RAS-GTPases through the RAF-MEK-ERK pathway, the first identified mitogen-associated protein kinase (MAPK) cascade is essential in development. A group of genetic syndromes, named "RASopathies", had been identified which are caused by...
Topics
- Child
- Child, Preschool
- Genetic Association Studies
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Infant
- Mitogen-Activated Protein Kinases
- Neoplasms
- Signal Transduction
- Syndrome
- ras Proteins