Article
Cancer in Noonan, Costello, cardiofaciocutaneous and LEOPARD syndromes.
American journal of medical genetics. Part C, Seminars in medical genetics - 15 May 2011
Kratz Christian P, Rapisuwon Suthee, Reed Helen, Hasle Henrik, Rosenberg Philip S
Abstract excerpt
Noonan syndrome (NS), Costello syndrome (CS), cardiofaciocutaneous syndrome (CFCS), and LEOPARD syndrome (now also referred to as Noonan syndrome with multiple lentigines or NSML) are clinically overlapping dominant disorders that are caused by mutations in RAS signaling pathway genes. The spectrum of cancer susceptibility in this group of disorders has not been studied in detail. We identified more than 1900...
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