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Aneuploidy in Cancer: Lessons from Acute Lymphoblastic Leukemia

17 Sept 2020

Abstract excerpt

Aneuploidy, the gain or loss of chromosomes in a cell, is a hallmark of cancer. Although our understanding of the contribution of aneuploidy to cancer initiation and progression is incomplete, significant progress has been made in uncovering the cellular consequences of aneuploidy and how aneuploid cancer cells self-adapt to promote tumorigenesis. Aneuploidy is physiologically associated with significant cellular...

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PMID: 32952102
DOI: 10.1016/j.trecan.2020.08.008

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