Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.

doi:10.1038/nn.4228

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Article

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.

Nature neuroscience - 1 Mar 2016

Franke Barbara, Stein Jason L, Ripke Stephan, Anttila Verneri, Hibar Derrek P, van Hulzen Kimm J E, Arias-Vasquez Alejandro, Smoller Jordan W, Nichols Thomas E, Neale Michael C, McIntosh Andrew M, Lee Phil, McMahon Francis J, Meyer-Lindenberg Andreas, Mattheisen Manuel, Andreassen Ole A, Gruber Oliver, Sachdev Perminder S, Roiz-Santiañez Roberto, Saykin Andrew J, Ehrlich Stefan, Mather Karen A, Turner Jessica A, Schwarz Emanuel, Thalamuthu Anbupalam, Shugart Yin Yao, Ho Yvonne Yw, Martin Nicholas G, Wright Margaret J, O'Donovan Michael C, Thompson Paul M, Neale Benjamin M, Medland Sarah E, Sullivan Patrick F

Abstract excerpt

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia...

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PMID: 26854805
DOI: 10.1038/nn.4228
PMCID: PMC4852730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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