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Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood.

Molecular psychiatry - 1 Dec 2022

Cheng Weiqiu, van der Meer Dennis, Parker Nadine, Hindley Guy, O'Connell Kevin S, Wang Yunpeng, Shadrin Alexey A, Alnæs Dag, Bahrami Shahram, Lin Aihua, Karadag Naz, Holen Børge, Fernandez-Cabello Sara, Fan Chun-Chieh, Dale Anders M, Djurovic Srdjan, Westlye Lars T, Frei Oleksandr, Smeland Olav B, Andreassen Ole A

Abstract excerpt

Patients with schizophrenia have consistently shown brain volumetric abnormalities, implicating both etiological and pathological processes. However, the genetic relationship between schizophrenia and brain volumetric abnormalities remains poorly understood. Here, we applied novel statistical genetic approaches (MiXeR and conjunctional false discovery rate analysis) to investigate genetic overlap with mixed...

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PMID: 36100668
DOI: 10.1038/s41380-022-01751-z

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