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Article

Diminished but Not Abolished Effect of Two His351 Mutants of Anthrax Edema Factor in a Murine Model.

Toxins - 2 Feb 2016

Zhao Taoran, Zhao Xinghui, Liu Ju, Meng Yingying, Feng Yingying, Fang Ting, Zhang Jinlong, Yang Xiuxu, Li Jianmin, Xu Junjie, Chen Wei

Abstract excerpt

Edema toxin (ET), which is composed of a potent adenylate cyclase (AC), edema factor (EF), and protective antigen (PA), is one of the major toxicity factors of Bacillus anthracis. In this study, we introduced mutations in full-length EF to generate alanine EF(H351A) and arginine EF(H351R) variants. In vitro activity analysis displayed that the adenylyl cyclase activity of both the mutants was significantly...

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Identifiers

PMID: 26848687
DOI: 10.3390/toxins8020035
PMCID: PMC4773788

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Source receipt: pubmed, retrieved 7 Sept 2026.

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