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Article

Bacillus anthracis oedema toxin as a cause of tissue necrosis and cell type-specific cytotoxicity.

Cellular microbiology - 1 Aug 2005

Voth Daniel E, Hamm Elaine E, Nguyen Lan G, Tucker Amy E, Salles Isabelle I, Ortiz-Leduc William, Ballard Jimmy D

Abstract excerpt

Oedema factor (OF) and protective antigen (PA) are secreted by Bacillus anthracis, and their binary combination yields oedema toxin (OT). Following PA-mediated delivery to the cytosol, OF functions as an adenylate cyclase generating high levels of cAMP. To assess OT as a possible cause of tissue damage and cell death, a novel approach was developed, which utilized a developing zebrafish embryo model to study...

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Identifiers

PMID: 16008581
DOI: 10.1111/j.1462-5822.2005.00539.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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